Pathological and immunohistochemical studies were performed on the lungs of 10 sheep with lesions of classical sheep pulmonary adenomatosis spa and six sheep with atypical lung tumours. Ha necessary for entry of virus, must be cleaved first. Ovine pulmonary adenocarcinoma opa, also known as ovine pulmonary adenomatosis, or jaagsiekte, is a chronic and contagious disease of the lungs of sheep and goats. Opa is caused by a retrovirus called jaagsiekte sheep retrovirus. Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity. Ovine pulmonary adenomatosis opa is an infectious lung cancer specific to sheep and is caused by jaagsiekte sheep retrovirus jsrv.
Cancer is a collection of diseases that result from uncontrolled cell growth. Ovine pulmonary adenocarcinoma, also known as ovine pulmonary adenomatosis, or jaagsiekte, is a chronic and contagious disease of the lungs of sheep and goats. First confirmation by pcr of jaagsiekte sheep retrovirus in ireland. Its latent period lasts from several months to years griffiths. In addition to sheep, goats and wild moufflon are also susceptible to. The virus causes an infectious, bronchiolaralveolar lung tumour of sheep. Ovine pulmonary carcinoma opc is a contagious pulmonary neoplasia with a suspected retroviral etiology. Progression from a normal cell to a fully malignant one is a multistep process, and numerous factors can contribute. The virus works by causing a proliferation of the alveolar lining cells in the lungs, causing mass amounts of fluid to be produced. Opa is believed to be the most important disease that.
These maps indicate the location of disease outbreaks reported in immediate notifications or followup reports. Jaagsiekte sheep retrovirus jsrv and enzootic nasal tumor virus entv are two smallruminant betaretroviruses that infect sheep, causing ovine pulmonary adenocarcinoma opa and enzootic nasal adenocarcinoma ena, respectively 1,2. Jaagsiekte ovine pulmonary adenomatosis was transmitted to newborn lambs by inoculation of the microsomal fraction of a cytoplasmic extract of cultured tumour cells or tumour tissue. Isolation and preliminary characterization of the jaagsiekte. Jaagsiekte sheep retrovirus jsrv is a type d retrovirus specifically associated with a contagious lung tumor of sheep, sheep pulmonary adenomatosis spa. This is the virus that killed dolly, the famous cloned ewe, at 6 years old. This section provides information about specific diseases. Jaagsiekte retrovirus is widely distributed both in t and. The disease is also commonly known as jaagsiekte, ovine pulmonary carcinoma or sheep pulmonary adenomatosis.
Various treatments of the biologically active fraction were carried out to differentiate between various classes of possible aetiological agents. Pulmonary adenomatosis of sheep, as seen in great britain, has been transmitted experimentally to sheep using a 10% fluid suspension of affected lung from field cases of the disease, administered by intrapulmonary injection or by repeated exposure to an aerial spray. Jaagsiekte sheep retrovirus jsrv is a unique oncogenic virus with distinctive biological properties. Jaagsiekte retrovirus is widely distributed both in t and b. Ovine pulmonary adenomatosis ovine pulmonary adenocarcinoma, jaagsiekte, opa is a disease caused by jaagsiekte sheep retrovirus jsrv a member of the genus betaretrovirus. Ovine pulmonary adenocarcinoma opa is a contagious lung tumour of sheep resulting from infection with a betaretrovirus called jaagsiekte sheep retrovirus jsrv. You can zoom in to examine an area of outbreaks in more detail. Ovine pulmonary adenocarcinoma results from infection by jaagsiekte sheep retrovirus jsrv, a member of the genus betaretrovirus in the.
The virus cannot be cultivated in vitro at present, but a procedure is described for the isolation and purification of small amounts in the form of immune complexes with iga from affected lungs. There are no efficient vaccination or treatment methods available. Visna meaning wasting is the term used in many parts of the world to refer to the neurologic form of the disease in sheep, resulting initially in unilateral pelvic paresis, progressing to. First confirmation by pcr of jaagsiekte sheep retrovirus in. It is known as visna when found in the brain, and maedi when infecting the lungs. Jsrv and entv share high nucleotide and amino acid identity and utilize the same cellular receptor, hyaluronoglucosaminidase2 hyal2, for entry 3,4. Opa is caused by a retrovirus called jaagsiekte sheep retrovirus jsrv. Ovine pulmonary adenocarcinoma opa is a naturallyoccurring neoplastic lung disease caused by the jaagsiekte sheep retrovirus jsrv 1518. Paraffinembedded ovine lung tissue from a field sample of ovine pulmonary adenocarcinoma opa.
Pdf diagnosis and phylogenetic analysis of ovine pulmonary. Ovine pulmonary adenocarcinoma opa, also known as jaagsiekte, is a transmissible lung tumour of sheep caused by jaagsiekte sheep retrovirus jsrv. Detection of jaagsiekte sheep retrovirus in the peripheral. Pathology and pathogenesis of ovine pulmonary adenocarcinoma. Visna is a descriptor in the national library of medicines controlled vocabulary thesaurus, mesh medical subject headings. Progressive pneumonia virus and maedi meaning dyspnea virus induce chronic progressive pneumonias that present with similar clinical signs. The experimental transmission of ovine pulmonary adenomatosis.
High infection rates and disease prevalence can develop during initial infection of flocks, leading to onfarm economic losses and animal welfare issues in sheep with advanced disease. Jsrv, a simple betaretrovirus, is the etiologic agent of ovine pulmonary adenocarcinoma, a form of nonsmall cell lung cancer in sheep and goats. Over the years, it has been shown that environmental factors e. Jaagsiekte sheep retrovirus infects multiple cell types in the ovine. Jsrv is an oncogenic retrovirus which causes lung epithelial cells type ii. Jaagsiekte, or ovine pulmonary adenomatosis, is caused by a recently discovered retrovirus. To determine the lesion development of retrovirusinduced ovine pulmonary carcinoma opc, ten neonatal lambs were inoculated intratracheally with either 1 lung fluid preparations derived from a sheep with type d retrovirusassociated opc and concurrent ovine lentivirus ovlvassociated lymphoid interstitial pneumonia lip n 8. Along with many rhinovirus subspecies and the picornaviruses, adenoviruses are among the causes of the common cold. Progressive pneumonia in sheep and goats respiratory system. Ovine pulmonary adenocarcinoma opa, caused by jaagsiekte sheep. Researched pathways related to pulmonary adenomatosis, ovine include oncogenesis, pathogenesis, tropism, localization, immune response.
Opa is caused by jaagsiekte sheep retrovirus jsrv, which induces oncogenic transformation of alveolar and bronchiolar secretory epithelial cells. Ovine pulmonary adenocarcinoma opa is a lung tumor of sheep caused by. However, subclinically infected sheep serve as a reservoir for the virus. Pulmonary adenomatosis, ovine harvard catalyst profiles. Lung cancer is the major cause of death among cancer. Ovine pulmonary adenocarcinoma results from infection by jaagsiekte sheep retrovirus jsrv, a member of the genus betaretrovirus in the retroviridae. There are 1520 copies of endogenous jaagsiekte sheep retrovirus. Maedivisna virus mvv and caprine arthritisencephalitis virus are commonly known as small ruminant lentiviruses srlvs due to their genetic, structural, and pathogenic similarities. Opa was first described in south africa in the 19th century where it was called jaagsiekte derived from the afrikaans for chasing sickness, because affected sheep have the appearance of having being chased and the. The term jaagsiekte sheep retrovirus jsrv is used in referring to this virus. Jaagsiekte sheep retrovirus is a descriptor in the national library of medicines controlled vocabulary thesaurus, mesh medical subject headings. March 2019 importance ovine pulmonary adenocarcinoma is caused by a virus that can be transmitted between sheep in respiratory secretions or milk. It has never been cultured from infected animals, which must be identified with viral nucleic acids or antigens. Ovine pulmonary adenocarcinoma caused by jaagsiekte sheep retrovirus.
Jsrv is also known as the pulmonary adenomatosis virus. Mycoplasma is the most common disease in backyard chickens and turkeys and predisposes to other diseases. All content on this website, including dictionary, thesaurus, literature, geography, and other reference data is for informational purposes only. You may have heard this disease called jaagsiekte, driving sickness or the wheelbarrow disease in reference to the huge volumes of fluid which can be produced from the lungs and the difficulty affected sheep display when subject to physical exertion such as being moved with a dog. Diagnosis and phylogenetic analysis of ovine pulmonary. Ovine pulmonary adenocarcinoma opa, also known as jaagsiekte is an infectious and fatal lung disease of sheep. Lung adenocarcinoma originates from retrovirus infection.
To see information from sixmonthly reports, please use the disease distribution maps. Progressive pneumonia in sheep and goats respiratory. Use the select box above to select the disease of interest, then click on any of the menu options on the left to view different types of information about that disease. Ovine pulmonary adenocarcinoma iowa state university. First confirmation by pcr of jaagsiekte sheep retrovirus. The disease is regarded as a valuable translational preclinical research model for studying human lung cancer, overcoming many of the limitations associated with current murine models. Here, we tested the hypothesis that jsrv envelopeinduced tumors are maintained by. Sheep with pulmonary adenomatosis exhibit progressive dyspnea, anorexia, and. Ovine pulmonary adenocarcinoma opa, a contagious lung cancer of sheep caused by an exogenous retrovirus known as jaagsiekte sheep retrovirus jsrv, is prevalent in many parts of india resulting in economic losses 1 4. Ovine pulmonary adenomatosis 1525 words 123 help me. But it could not receive considerable importance in the control and eradication programmes due to lack of availability of rapid serological diagnostic techniques. Jaagsiekte sheep retrovirus jsrv is the etiologic agent of ovine pulmonary adenocarcinoma opa palmarini and fan, 2001, 2003. Ovine pulmonary adenocarcinoma opa is a contagious, viral, neoplastic disease of the lungs of sheep and more rarely of goats.
Sheep bac is caused by the jaagsiekte retrovirus jsrv and is contagious. Jsrv has been described in various breeds of sheep, rarely in goats, and does not appear to infect other animals 4, 5. Visna virus also known as visnamaedi virus, maedivisna virus and ovine lentivirus from the genus lentivirus and subfamily orthoretrovirinae, is a prototype retrovirus that causes encephalitis and chronic pneumonitis in sheep. Diagnosis and prevalence of ovine pulmonary adenocarcinoma in. In addition to sheep, goats and wild moufflon are also susceptible to the virus 6. Jsrv is the only virus causing a naturally occurring lung cancer ovine pulmonary adenocarcinoma, opa and possessing a major structural protein that functions as a dominant oncoprotein. Pulmonary adenomatosis, ovine is a descriptor in the national library of medicines controlled vocabulary thesaurus, mesh medical subject headings. Lifelong, persistent infections in sheep occur in the lungs, lymph nodes, spleen. This article presents images from ultrasound and postmortem examination of opa lesions, and other common lung pathologies in adult sheep. Lung cancer in mice induced by the jaagsiekte sheep.
It has been reported from europe, asia, africa, and south and north america. Lung tumour samples and other tissues from the same 16 animals were tested for the presence of jaagsiekte retrovirus jsrv by a polymerase chain. Jsrv replicates actively in the transformed epithelial cells of the lung, and jsrv dna and rna have been detected in lymphoid tissues of naturally affected animals. Jaagsiekte sheep retrovirus jsrv is an oncogenic betaretrovirus that. Transmission is through inhalation of infectious virus or direct contact with infected respiratory secretions. Opa jaagsiekte moredun group moredun research institute. Another case study in our series about the diseases that arent always in the news. Eradication programs have been based on extensive slaughtering, because no. Ovine pulmonary adenocarcinoma opa, caused by jaagsiekte sheep retrovirus jsrv, is characterised by the development of invariably fatal lung tumours primarily in adult sheep. Ovine pulmonary adenocarcinoma, ultrasound ovine pulmonary adenocarcinoma opa is a contagious, viral, neoplastic disease of the lungs of sheep and more rarely of goats. This page does not display information from sixmonthly reports. Ultrasonography of ovine pulmonary adenocarcinoma phil scott, chris cousens doi. Evaluation of the efficacy of clinical diagnosis of ovine pulmonary adenocarcinoma. Ovine pulmonary adenocarcinoma ovine pulmonary adenomatosis, ovine pulmonary carcinoma, jaagsiekte, sheep pulmonary adenomatosis last updated.
Retrovirusassociated ovine pulmonary carcinoma sheep. Opa is a significant disease in many sheeprearing countries in europe, africa, asia, and the americas sharp and demartini, 2003. Pulmonary adenomatosis, ovine pulmonary adenomatosis, ovine is a descriptor in the national library of medicines controlled vocabulary thesaurus, mesh medical subject headings. This is a type b retrovirus with a genome composed of linear, positive, single stranded rna. The study of pulmonary adenomatosis, ovine has been mentioned in research publications which can be found using our bioinformatics tool below. Ovine respiratory syncytial virus definition of ovine. The major core protein p27 of the putative opc virus crossreacts with antibodies to p27. Ovine pulmonary adenocarcinoma opa is a transmissible lung cancer of sheep. Ovine pulmonary adenocarcinoma opa is a contagious lung cancer of sheep previously known as sheep pulmonary adenomatosis and ovine pulmonary carcinoma. Ovine pulmonary adenocarcinoma opa, also known as ovine pulmonary adenomatosis and jaagsiekte, is a contagious neoplasm affecting the lungs of sheep, which is caused by jaagsiekte sheep retrovirus jsrv. At present, diagnosis of opa relies on clinical and pathological investigations. It has been shown that the envelope protein alone is sufficient to induce tumorigenesis in the lungs of mice when delivered via an adenoassociated viral vector. Vet emily gascoigne considers ovine pulmonary adenomatosis opa virus in sheep flocks.